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Within a murine model of acute infection, we found that treatment of infected mice, using dosage comparable to those previously trialled in human safety studies, significantly reduced parasite burden compared to vehicle-treated controls (Fig 5C)
Having one or more of these polymorphisms is associated with an increased risk of certain diseases, especially when impacted by environmental triggers such as pollution, smoking, heavy metals, and other toxins
While mammalian cells and the infected mouse hosts obviously tolerated the dosage of AF used in our studies, the results presented here show that larval, juvenile, and adult parasites are extremely sensitive to killing by AF
Bioessays 2010;32:422-9
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