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The Phase 2 and Phase 3 trials so far have shown a safety profile broadly consistent with other GLP-1 medications: gastrointestinal side effects are common, and a new signal called dysaesthesia (an abnormal skin sensation) appears more often at higher doses
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Bloomer, R
Microcirculation is responsible for supplying blood flow, oxygen, and nutrients to tissues through regulating vascular resistance at the precapillary level
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