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Despite the new class of GLP-1 agonists, there remain only 5 FDA-approved medications to treat obesity, highlighting a clear need for additional pharmacotherapy
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation
This is achieved by preventing the activation of nuclear transcription factor-kappa-B (NF-B) (reviewed in [4])
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