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When stimulated with interferon-gamma (IFN-), bacterial lipopolysaccharide (LPS) and granulocyte-macrophage-colony-stimulating factor (GM-CSF), monocytes differentiated into M1 macrophages, which can secrete IL-1, IL-12, TNF and CXCL12 (Sica et al., 2008

Loss of MPC function leads to cytosolic pyruvate accumulation and impairs entry into the tricarboxylic acid (TCA) cycle, thereby shifting cells toward a glycolytic phenotype and promoting resistance to OXPHOS inhibition [18]

The total cell counts and total protein concentration in BALF, indicators of cellular infiltration and increased alveolar permeability, respectively, were significantly elevated by LPS

Ferroptosis is a new form of programmed cell death that plays an essential role in the development of cardiovascular disease