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It is primarily metabolized via glucuronidation and mitochondrial beta-oxidation, usually with a minor contribution from CYP2C9 and CYP2C19
Multiple other users report losing 20-50 pounds over 3-6 months, consistent with what clinical data on semaglutide predicts for motivated users who maintain dietary changes alongside the medication
Ozempic does not typically cause digestive enzyme deficiency
The second, more sustained phase occurs when nutrients directly contact L-cells in the lower small intestine and colon, producing a more prolonged GLP-1 release that continues for several hours after a meal
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