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When cholesterol was added, an increase in membrane stiffness was observed, but the stiffening extent decreased with increasing chain unsaturation, indicating the dominance of cholesterols stiffening effect over PUFA-induced softening [175]
But high Estrogen also plays a large role in all of this in both women and men, building excess body fat and lowering testosterone and growth hormone
The medication may not work as well if injected into damaged tissue
So it takes us back in history, but there was a period between World War II and 1970s where there was a lot of motivation in the research community to do these grand randomized controlled trials of nutrition
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