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Abbreviations ACS: Acute chest syndrome AD: Alzheimers disease AF-6: Afadin-6 AGEs: Advanced glycation end-products AJs: Adherens junctions AKT: Protein kinase B ALS: Amyotrophic lateral sclerosis APP: Amyloid precursor protein AQP-4: Aquaporin 4 ARPE-19: Retinal pigment epithelia cell line ATP: Adenosine triphosphate A: Amyloid beta BBB: Blood-brain barrier BCRP: Breast cancer resistance protein bFGF: Basic fibroblast growth factor BRB: Blood retinal barrier BSCB: Blood-spinal cord barrier BTB: Blood tumor barrier -NAD: Beta-nicotinamide adenine dinucleotide CAMs: Cell adhesion molecules Ca2 + : Extracellular calcium CAR: Coxsackievirus and adenovirus receptor CCI: Chronic constriction injury CCL2: C-C motif chemokine ligand 2 ceRNA: Competing endogenous ribonucleic acid CNS: Central nervous system CSF: Cerebrospinal fluid CypA: Cyclophilin A Dpi: Days post injury EAE: Experimental autoimmune encephalomyelitis EGCG: Epigallocatechin gallate EPCs: Endothelial progenitor cells ERK1/2: Extracellular signal-regulated kinases ESAM: Endothelial cell-selective adhesion molecule ESCs: Embryonic stem cells EVs: Extracellular vesicles FGF: Fibroblast growth factor FITC: Fluorescein isothiocyanate GBD: Global burden of disease GBM: Glioblastoma multiforme GD-DTPA: Gadolinium-diethylenetriamine pentaacetic acid GDNF: Glial cell line-derived neurotrophic factor GFAP: Glial fibrillary acidic protein GLUT: Glucose transporters Gp120: Envelope glycoprotein GSH: Glutathione HD: Huntingtons disease HIV: Human immunodeficiency virus HIVE: HIV encephalitis ICAM-1: Intercellular adhesion molecule IgG: Immunoglobulin IL: Interleukin IL-1: Interleukin-1 beta iNSCs: Induced neural stem cells iPSCs: Induced pluripotent stem cells JAM-L: Junctional adhesion molecule-like JAMs: Junctional adhesion molecules KO: Knock out LPS: Lipopolysaccharide LSR: Lipolysis-stimulated lipoprotein receptor MAGUK: Membrane-associated guanylate kinase MAPK: Mitogen-activated protein kinase MARVEL: Myelin and lymphocyte and related proteins for vesicle trafficking and membrane link MCAO: Middle cerebral artery occlusion MCP-1: Monocyte chemoattractant protein-1 miRNA: Micro RNA MLCK: Myosin light chain kinase MMP: Matrix metalloproteinases MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MRI: Magnetic resonance imaging MS: Multiple sclerosis MSCs: Mesenchymal stromal cells nBP: n-Butylidenephthalide L-NAME: N G -nitro- l -arginine methyl ester NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NP: Neuropathic pain NSCs: Neural stem cells NVU: Neurovascular unit PDGF: Platelet-derived growth factor PECAM-1: Platelet/endothelial cell adhesion molecule-1 PRDX1: Peroxiredoxin 1 PI3K: Phosphatidylinositol 3-kinase PKC: Protein kinase C PPAR: Peroxisome proliferator-activated receptor- RAR-: Retinoic acid receptor alpha relBOP: Repeated low-intensity blast overpressure RNAi: RNA interference RPE: Retinal pigment epithelium SCD: Sickle cell disease SCI: Spinal cord injury SE: Status epilepticus Ser: Serine SHRs: Spontaneously hypertensive rats SOD1: Superoxide dismutase 1 STN-DBS: Subthalamic deep brain stimulation STZ: Streptozotocin Tat: Transactivator of transcription TBI: Traumatic brain injury TDP43: TAR DNA-binding protein 43 TEER: Transepithelial/transendothelial electrical resistance TEMPO: 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl TGF-: Transforming growth factor beta Thr: Threonine TJ: Tight junction TNF: Tumor necrosis factor-alpha TRPM7: Transient receptor potential melastatin 7 Tyr: Tyrosine VCAM-1: Vascular cell adhesion molecule-1 VE-Cadherin: Vascular endothelial cadherin VEGF: Vascular endothelial growth factor WHO: World Health Organization ZO-1: Zonula occludens 1 References Hyman S, Chisholm D, Kessler R, Patel V, Whiteford HA (2006) Mental disorders in disease control priorities in developing countries

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