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However, the review notes that these results, while promising, remain preliminary and require confirmation in larger outcome studies

However, monitor liver enzymes at baseline and periodically during treatment to distinguish beneficial reductions from rare cases of drug induced liver injury

Nature 523 , 177182 (2015)

Fever or signs of infection Severe abdominal pain Unexplained weight loss No bowel movement for more than 5 days Blood in stools Bleeding during bowel movements These symptoms can be serious and may indicate complications such as gastrointestinal bleeding, bowel obstruction, or other conditions that require immediate medical evaluation