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A GGT gene family exists in the human genome (Table I), suggesting that regulating GGT activity may be associated with activating different GGT genes rather than identifying distinct gene loci (26)

doi: 10.1039/D0FO02501A 163 ZhangHYangLWangYHuangWLiYChenSet al

5-fluorouracil-induced mitochondrial oxidative cytotoxicity and apoptosis are increased in MCF-7 human breast cancer cells by TRPV1 channel activation but not hypericum perforatum treatment

For instance, PDE4 inhibitors such as roflumilast, used in COPD, frequently induce gastrointestinal and CNS-related side effects, including diarrhea, nausea, headache, insomnia, and weight loss (Janjua et al., 2020