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However, tirzepatide treatment resulted in mild to moderate gastrointestinal symptoms, including nausea (1224%), diarrhea (1517%) and vomiting (610%)

The evidence clearly indicates that weight loss medication must be taken long-term or lifelong if weight is to be maintained, and that GLP-1 receptor agonists should be used as an integrated tool within long-term, multidisciplinary treatment not as an isolated intervention because weight loss medication cannot stand alone

Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model

Weight gain of this nature is often refractory to diet and exercise leaving many patients without the hope of improvement