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[15] [16] Those taking Wegovy should be aware of and report any changes in mood or thoughts of suicide or self-harm, as suicidal ideation has been reported
Research on tirzepatide specifically shows that it promotes the apoptosis (programmed death) of M1-type macrophages, the inflammatory phenotype, while reducing their inflammatory factor secretion by inhibiting ERK phosphorylation
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In the brain, GLP-1 receptors are found in regions integral to appetite regulation, including the hypothalamus, brainstem, and reward-processing areas such as the nucleus accumbens and ventral tegmental area
