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In the SUSTAIN-6 trial involving over 3,000 people with type 2 diabetes and established heart disease, semaglutide reduced triglycerides by approximately 20% compared to placebo
Rather than relying on a single mechanism, the stack emphasizes formulation synergy, reflecting principles derived from endocrine and performance research
In these cases, switching to a different glucose-lowering agent or stopping metformin altogether may improve tolerability
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