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Graphical Abstract 1 Introduction Acute pancreatitis (AP) is a life-threatening inflammatory disorder characterized by premature activation of pancreatic enzymes, leading to autodigestion, edema, hemorrhage, and necrosis of pancreatic tissues (Mederos et al., 2021)

Persistent, spreading, or blistering reactions are a signal to stop entirely and seek professional evaluation, since these may indicate a true allergy rather than ordinary transient irritation

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