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Large-scale clinical trials with semaglutide (STEP 1) found that roughly 40% of total weight loss came from lean body mass (LBM), which is higher than the roughly 25% expected during typical physiological weight loss (the so-called "quarter fat-free mass rule")

Blue Skye Health and Wellness takes a personalized and evidence-informed approach, using advanced therapies and ongoing monitoring to help guide your body toward better function over time

They considered it a hurdle to the procedure, says Mitchell, who had a body mass index of 40 at that point, which is sometimes categorized as severe obesity

eligibility criteria and service requirements should be confirmed against the current NICE TA at the time of prescribing