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Diabetes and weight-loss trials have shown that the GLP-1 drugs target hormones in the gut and the brain that control appetite and feelings of fullness, cutting down on what's described as food noise, or intrusive thoughts of food
Research priorities now, include adequately powered randomised controlled trials (stratified by obesity status), mechanistic studies linking mucosal GLP-1 signalling to clinical endpoints and longer-term safety surveillance
Self-reported community sources describe: Nausea scaling with per-dose amount
Berberine and health outcomes: an umbrella review
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