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Other recognised side effects include: Fatigue and dizziness Headache Injection site reactions (redness, itching) Increased heart rate (typically modest) Gallbladder problems , including gallstones and cholecystitis (risk increased with rapid weight loss) Hypoglycaemia (mainly when used alongside insulin or sulfonylureas in people with diabetes) Risk of dehydration and acute kidney injury with severe gastrointestinal symptoms Diabetic retinopathy complications in people with pre-existing retinopathy Rare but serious adverse effects include pancreatitis (inflammation of the pancreas), which requires immediate medical attention if severe abdominal pain develops

For more details regarding the early studies on body Se transport, the reader is referred to the review by Chen and Berry (2003)

These variables can all affect your experience with the same 50-unit draw, and noting them helps isolate what is actually causing any changes you observe

Semaglutide, meanwhile, interacts only with the GLP-1 receptor