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Significantly, the dual effect of glitazones to increase GDH flux while reducing NHE activity decreases proliferation(NHE) but increases cell survival(GDH) resulting in only a slight decrease in cell number[26]
If unusual symptoms such as eruption, pale face, blood pressure drop, or difficulty in breathing occur during therapy, discontinue the drug immediately
Cell-culture time courses Cell-culture studies in tendon-derived and fibroblast cell populations report observable changes in cellular migration, proliferation kinetics and gene-expression in growth-factor pathways over a window of hours to several days
6d), while the risk of death with late-life L2-Cmu treatment was 62.2% (40.7%, 95.2%) of that observed for controls ( P = 0.029)
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