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Metformin immediate-release is taken by mouth twice daily, while the extended-release formulation allows once-daily dosing

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This is sometimes referred to as sarcopenic obesity, or "skinny fat." Individuals may appear thin or have a normal body weight but the combination of body fat relative to low muscle mass is associated with increased health risks, similar to those seen in both obesity and sarcopenia (e.g., insulin resistance, type 2 diabetes, cardiovascular disease, and decreased physical function and mobility)

This can lead to some super cool before and after photos