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Insurance coverage varies widely, with some plans requiring prior authorization, step therapy (trying cheaper medications first), or denying coverage altogether

Intermediates of the TCA cycle were also significantly decreased in biofilm lawns compared to suspended cultures, including alpha-ketoglutarate (FC = 0.07, p = 3.19 10 -3 ), succinate (FC = 0.08, p = 6.25 10 -6 ), pyruvate (FC = 0.22, p = 1.88 10 -3 ), and fumarate (FC = 0.32, p = 2.87 10 -2 )