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Currently, the lysine lactosyltransferases that directly transfer lactate for lactylation are mainly members of the aminoacyl-tRNA synthetase (AARS) family, whose usual function is to catalyze the ligation of l-alanine to tRNA
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The following sections examine how these core mechanisms translate into condition-specific effects across major cardiovascular pathologies, highlighting how metformins multifaceted actions may offer therapeutic value across diverse cardiac settings
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