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All neurodegenerative diseases exhibit significant metabolic impairment, including decreased glucose uptake or utilization, with a consequent diminution in ATP production (59)
The American Diabetes Association Standards of Care emphasize that apparent loss of effectiveness should prompt a comprehensive reassessment rather than automatic dose escalation
It may be reasonable to hold the GLP-1 RA if no other cause for infertility is found, although evidence does not strongly implicate the drug in most cases
PHQ-9, Patient Health Questionnaire 9
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