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Yamazaki H, Kushiyama A, Sakoda H, Fujishiro M, Yamamotoya T, Nakatsu Y et al (2018) Protective effect of sex hormone-binding globulin against metabolic syndrome: in vitro evidence showing anti-inflammatory and lipolytic effects on adipocytes and macrophages
When GLP-1 binds to specific receptors in the body, it triggers a series of mechanisms that regulate blood sugar levels, slow the movement of food through the digestive system and act on neurons in the brainall of which give people a feeling of fullness that helps them eat less and lose weight
Annexin V binds phosphatidylserines that translocate to the outer leaflet of the membrane during early apoptosis 61 , whereas 7-AAD is a membrane-impermeable DNA dye that labels cells with compromised membrane integrity, identifying cells undergoing lytic forms of cell death such as necrosis, secondary necrosis and pyroptosis 62,63
Semaglutide stands as a testament to the power of medicinal chemistry to take a biological lead and engineer it into a more effective and convenient therapeutic agent.
