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Using culture techniques, the majority of bacteria identified as facultative anaerobes in human milk belong to the Staphylococcus and Streptococcus species and other species in smaller numbers ( Propionibacterium, Rothia, Enterococcus , and Lactobacillus species) ( Bifidobacterium and Bacteroides species ( Staphylococcus, Streptococcus , and Propionibacterium ( The actual origin of the milk microbiota remains uncertain ( Human milk directly contributes to the establishment of the intestinal microbiota and facilitates a symbiosis between that microbiota and the infant by providing essential nutrients, in particular milk glycans or HMOs, for microbial metabolism ( via signaling pathways ( Bacteroides and Bifidobacterium , induce mucosal glycan production, which further supports microbial growth, and the microbes convert indigestible milk glycans to absorbable short-chain fatty acids ( via specific bioactive factors reaching the infant

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Researchers suggest Receptor Grade IGF-1 LR3 has the potential to induce a signaling mechanism in the organism, either via autocrine mode (where the tissue cell stimulates itself) or via paracrine mode (where the tissue cell stimulates the nearby cell)