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This ferroptosis cascade is pharmacologically mitigated by dexmedetomidine-argon co-administration, which blocks TXNIP mitochondrial translocation to preserve redox homeostasis (99)

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Monooxygenases act by sequentially transferring two electrons from NADH or NADPH to one of the two atoms of oxygen in O 2 , generating H 2 O from one oxygen atom and incorporating the other oxygen atom into an organic compound as a hydroxyl group (R-OH)