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Hideyuki Akaza, Jae Kyung Roh, Xishan Hao, Suwit Wibulpolprasert, Shinjiro Nozaki, EunCheol Park, Takashi Fukuda, Shigeto Sonoda, Norie Kawahara Cancer Science.2016

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The botulinum toxin injection immobilizes a small part of the sphincter muscle for 4-6 months , allowing the wound to heal calmly and painlessly due to the improved blood flow