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Surgery carries: Operative risks Potential long-term nutritional deficiencies Requires lifelong follow-up Weighing Non-Invasive Peptide Therapy Against Bariatric Surgery in Obesity Management Peptide therapy, including tirzepatide peptide drugs, offers significant, sometimes comparable weight loss without surgery, but it usually requires ongoing treatment to maintain the effect

Rybelsus is licensed for type 2 diabetes at lower doses, and its weight-loss effect is more modest than the new 25 mg oral Wegovy

Antonoff, MB , Donington, J, Husain, SA, Kaneko, T, Kilic, A, Pereira, SJ