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It is important to understand that these in vitro models express a different hormonal cocktail and respond to different chemical stimuli than intestinal L-cells in vivo ( The more physiologically relevant studies make use of in vivo transgenic mice, ex vivo perfused intestines or, more recently, crypt organoids derived from human, mouse or porcine guts ( In situ immunostaining and FACS studies have demonstrated that the hormonal secretome of GLP-1-secreting-cells is anatomically dependent
In the new Lemme formula, it is blended with black ginger, which is traditionally used to support energy and metabolic activity, along with chromium, methylated vitamin B12, and vitamin B6 to support energy metabolism and overall cellular health
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