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: ,
It contains charantin and polypeptide-p , both of which have insulin-like effects
This ERMCS-localised GLP-1R signalling hub requires the engagement of the AKAP SPHKAP, known to assemble PKA-RI aggregates at the ER 32,33 , with VAPB playing a central role as the tethering factor responsible for the separate recruitments of GLP-1R and SPHKAP to ERMCSs, the latter via the direct interaction of VAPB with the pFFAT motif of SPHKAP
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