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Long-term drug therapy and drug discontinuations and holidays for osteoporosis fracture prevention: a systematic review

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Consider holding medication and obtaining prompt evaluation if ALT/AST exceed 3 upper limit of normal with symptoms or bilirubin elevation, or if levels exceed 5 upper limit of normal even without symptoms

Lilly has seven additional Phase 3 readouts expected before year's end, including TRIUMPH-2 in obesity plus type 2 diabetes and TRIUMPH-3 in obesity plus established cardiovascular disease

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