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Ipamorelin (GHRP, activates GHSR-1a on somatotrophs) and CJC-1295 (GHRH analog, activates GHRHR on somatotrophs) stimulate growth hormone release through two complementary receptor pathways on the same pituitary cell type

Tirzepatide is a dual agonist that targets glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

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In addition, beneficial bacterial metabolites and enzymes can influence the metabolism of xenobiotics and reactive oxygen species directly or indirectly by regulating the expression and function of key antioxidant liver enzymes (Clarke et al., Lactobacillus species have been reported to have antioxidant properties that work against heavy metal-induced oxidative stress in mice (Srednicka et al., has been shown to have high levels of antioxidant molecules and glutathione compared with L