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While immune activation can effectively clear damaged mitochondria (Harding et al., 2023), immune dysfunction has been reported to trigger mitochondrial impairments and thereby increase the oxidative damage within the cell (Tresse et al., 2021)
Residual activity on VAMP1 (residues 2888), however, highlighted the need for negative selection (Extended Data Fig
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T-DM1 was also administered to 11 patients with HER2 -amplified NSCLC included in the former basket trial and achieved an ORR of 55% (95% CI, 23 to 83) [24-26] and Peters et al
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