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We separate these two compounds by mechanism and preclinical evidence, and explain why researchers run them together

Previous study reported that although Nrf2 deficiency may reduce trabecular bone mass, compensatory bone remodeling or individual differences could lead to higher trabecular bone in some KO mice 53 , which also highlighted the functional diversity of Nrf2

25 The Val 23 and Ile 27 used in tirzepatide are likely to have little impact on either GLP-1 or GIP activity because they are the same kind of residue and no specific interaction in these sites has been detected