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According to NICE guidance and MHRA safety information, healthcare professionals should maintain vigilance for rare but serious adverse effects including acute pancreatitis, gallbladder disease, and potential thyroid tumours (based on animal studies, though human risk remains uncertain)

Route confusion: animal studies used IP/IV

For patients with heart failure taking beta-blockers, optimization of beta-blocker dosing should be prioritized to maintain target heart rate goals in accordance with heart failure guidelines

These benefits were still apparent and even larger for some conditions a year later, and tirzepatide users were also less likely to die of any cause