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Dose-response relationships: Preclinical studies employed single-dose or limited-frequency protocols, leaving repeated high-dose exposure effects uncharacterized
In one study, patients regained about two-thirds of the weight they had lost just one year after stopping semaglutide treatment, and their cardiometabolic risk markers (blood sugar, cholesterol, etc.) reverted toward baseline (source)
Liraglutide for the treatment of obesity among patients with hidradenitis suppurativa
Operations like the gastric sleeve or gastric bypass typically help patients lose 7080% of their excess body weight, while also improving type 2 diabetes, high blood pressure, and cholesterol
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