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Observational studies suggest that GLP-1RA therapy may be associated with changes in musculoskeletal parameters under conditions of rapid weight loss [34, 40]

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In reality, combining both methods yields the best results

GLP-1 and SGLT-2 have the highest level of clinical evidence for use in this population, per the American Diabetes Association (ADA) guidelines.[3] Both GLP-1 and SGTL-2 products, such as Jardiance, have the ability to improve blood glucose control (hemoglobin A1c reduction), potentiate weight loss and provide a cardiovascular protective effect