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Similar to eukaryotic systems such as YESS-NGS 55 , this bacterial approach offers the ability to profile natural and evolved proteases in parallel on thousands of natural and synthetic substrates through high-throughput sequencing without requiring protein purification

Blood 66:294297 Fitzgerald RK, Johnson A (2001) Pulse oximetry in sickle cell anemia

These include nausea (affecting 15-44% of users depending on dose), diarrhea (10-30%), vomiting (7-25%), constipation (6-24%), and abdominal pain or discomfort (approximately 9%)

Widmarks foundational research in the 1920s and refined through decades of forensic toxicology study, reflect the average difference in body water content between the two sexes