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P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells
10.3389/fphar.2021.731609 162 WangY.HanY.ShangS.XiaoJ.TaoL.PengZ.et al (2024b)
Adv Sci 2025;12:e2412593
Pinealon neuroprotective properties are particularly relevant for menopausal women experiencing both sleep disruption and cognitive fog, as both conditions share underlying neural mechanisms
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