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Discussion To date, the clinical development program suggests that lixisenatide has an appropriate pharmacodynamic action, with reductions in blood glucose, in particular marked reductions in PPG, manifesting as improvements in glycemic control, a beneficial effect on body weight, and with limited risk of hypoglycemia with 20 g OD dosing

Even further from clinical translation are gene-, cell-, and mitochondrial-based therapies, where evidence is still predominantly preclinical, though early signals are encouraging

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