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For instance, MC4R agonism in the nucleus accumbens altered dendritic morphology and increased behavioral sensitization to drugs of abuse

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For those experiencing muscle discomfort, healthcare providers recommend: Maintaining adequate protein intake Setting daily hydration goals Incorporating both cardiovascular and strength training exercises Regular monitoring of body changes and fatigue levels It's worth noting that what some patients perceive as muscle pain might be related to other side effects, particularly gastrointestinal issues like gallstones or pancreatitis, which may manifest as muscle aches or back pain

Animal studies provide limited insight