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[END CALLOUT BOX] GLP2 Pharmacokinetics & Metabolism Absorption & Distribution Following subcutaneous administration, GLP2 exhibits favorable pharmacokinetic properties enabling once-weekly dosing: Mean absolute bioavailability of approximately 80% after subcutaneous injection Time to maximum plasma concentration (Tmax) ranges from 8 to 72 hours Steady-state plasma concentrations achieved after 4 weeks of once-weekly dosing Mean steady-state volume of distribution approximately 10.3 L, indicating limited tissue distribution The high plasma protein binding to albumin (99%) results from the C20 fatty diacid modification, which provides prolonged systemic exposure and enables sustained therapeutic effects between weekly doses
The NHS advises that taking up to 2 mg (2000 micrograms) of vitamin B12 daily in supplements is unlikely to cause harm in healthy individuals
The trial found it was well tolerated with injection site reactions as the most common side effect
You feel full longer, which helps reduce cravings and the urge to eat
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