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Leaving semaglutide out of the fridge too long
The choice between the two should be based on individual preferences and medical guidance
However, unlike Ozempic and Wegovys active ingredient, tirzepatide works on a second hormone receptor, GIP (glucose-dependent insulinotropic polypeptide), which some studies suggest is more effective than semaglutide for blood sugar control and weight loss
Note, however, that pyruvate is a potent negative effector on all PDKs, with the result that when pyruvate levels rise, active PDH will be favored even with high levels of NADH and acetyl-CoA
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