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Furthermore, a recent 2024 study highlighted the critical role of CD8 T-cell dysfunction in both ME/CFS and Long COVID, noting that these immune cells produce markedly less necessary cytokines when exhausted by oxidative stress

Current research limitations include the absence of large-scale randomized clinical trials in humans, an still partial understanding of the precise molecular mechanisms, and a lack of detailed pharmacokinetic data in humans

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10.1080/08923973.2016.1274997 40 RaineT.BonovasS.BurischJ.KucharzikT.AdaminaM.AnneseV.et al (2022)