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The molecular structure of GLP-1 peptides is large, hydrophilic, and electrically charged, which severely limits the ability of the molecule to pass the outer layer of the skin and enter the bloodstream, says Edwin Davila, DO, resident physician and obesity medicine expert for the National Academy of Sports Medicine

Rogers AW, Radlinski LC, Nguyen H, Tiffany CR, Carvalho TP, Masson HL, Goodson ML, Bechtold L, Yamazaki K, Liou MJ, Miller BM (2024) Salmonella re-engineers the intestinal environment to break colonization resistance in the presence of a compositionally intact microbiota

These are important for supporting healthy circulation, bone density, nerve signaling functions, heart health and digestive health

We tested therefore also mutants impaired in the three genes SULTR1;2 , SULTR4;1 and SULTR4;2 encoding sulfate transporters 64,65,66 but did not observe an altered susceptibility to AITC