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SASP (senescence-associated secretory phenotype) results revealed that FOXO4-DRI downregulates the levels of IL-1 , IL-6 , IL-8 , and TNF- (Figure 4H)

Purity tested Endotoxin tested Heavy metals tested

References Zeyner, A., & Harmeyer, J

This study suggested several T1D susceptibility genes that also contribute to TPOAb levels, including STAT4, BACH2, UBASH3A, PTPN22, CTLA4, IL2, RASGRP1, SH2B3, FCRL3, FCRL1, IL2-IL21 and SPPL3 32 , pointing that there are possibly more undiscovered TPOAb and TgAb loci that are also involved in the development of other non-thyroid diseases characterized by the presence of thyroid antibodies