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Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome cRelease
This biphasic response reflects the dual role of ROS in TGF- regulation: moderate ROS activate latent TGF- complexes and promote Smad phosphorylation via redox-sensitive kinases such as p38 MAPK and JNK, whereas excessive ROS inhibits TRII and Smad3 phosphorylation 72
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Evidence ranges from early laboratory work to clinical trials depending on the use the sections below cover the actual data and sources
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