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Case report and literature review
The most common include: Nausea (usually temporary and decreases over time) Gastrointestinal discomfort Constipation or diarrhea Fatigue in the initial weeks In my Miami practice, Ive found that starting with lower doses and gradually increasingalong with specific dietary recommendationssignificantly reduces these side effects
Others who choose to take pills or subdermal supplements may notice a more gradual effect, sometimes taking a few weeks before their symptoms improve
Studies have also proposed a role in ryanodine receptor modulation, interleukin-1 (IL-1) secretion and endoplasmic reticulum stress-mediated autophagy 7,12,13,14,15
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