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This finding is particularly relevant because changes in albuminuria have been consistently linked to subsequent risk of KF [30]
Despite its therapeutic efficacy, tacrolimus has a narrow therapeutic window (520 ng/mL whole blood 1012 h post-dose) and frequently displays episodes of toxicity, such as nephrotoxicity, neurotoxicity, and glucose intolerance (Chow et al., 1997)
Received: Accepted: Published: Version of record: Issue date: DOI:
As we explore these medications further in the following sections, we will discuss their clinical benefits, the therapeutic challenges they pose, and the cutting-edge research that continues to uncover their full potential
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