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Storage temperature exceeded if the medication has been exposed to temperatures above the product-specific limit (check your leaflet/SmPC) for extended periods, it should be discarded

To prevent the medication from being contaminated by microorganisms, make use of sterile equipment and adhere to aseptic practices

First, variations in the initial measurements of certain endpoints (e.g., frequency, intensity, MIDAS score, and duration) may have affected the reliability of the findings