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The side effects of GLP-1 RAs can include gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which are usually transient but may affect patient adherence, as well as rarer complications that require careful monitoring in clinical practice
In addition to this, GLP-1RAs may directly improve hepatic steatosis via the upregulation of fatty acid metabolism and insulin signalling pathways [12]
In practical portfolio terms, Novo is doing what the market rewards: prove the maximal efficacy franchise first in the route with the highest probability of success, then decide whether oral conversion is worth the additional complexity
Mayor riesgo de niveles bajos de azcar en sangre (hipoglucemia), especialmente en aquellas personas que tambin toman medicamentos para la diabetes, como insulina o sulfonilureas
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