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For example, GLP-1R agonism has been shown to reduce cocaine-seeking behaviors in mice, as measured by intravenous self-administration (IVSA) paradigms (Sorensen et al., 2015)

Important Considerations Individual Variation: L-cell density and function vary significantly between individuals based on genetics, age, gut health history, and metabolic status

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Tirzepatide is actively studied in research on dual incretin receptor pharmacology, adipose tissue biology, beta-cell preservation, NASH resolution, obstructive sleep apnea, heart failure with preserved ejection fraction (HFpEF), and polycystic kidney disease